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N.O. Limits

N.O. Limits

180 Caps
$22.99


Through the promotion of blood flow and positive nutrient partitioning, Nitric Oxide (NO) has found an elite place amongst bodybuilding and fitness enthusiasts looking to improve their physique. While some products merely doan adequate job of accomplishing this goal, the ideal NO product can produce a proverbial “skin-tearing” pump that provides the perfect physical and mental motivation for training; a product that makes you feel unstoppable in the gym. It is with this concept in mind that Designer Supplements introduces N.O. Limits™, the evolutionary next step in Nitric Oxide signalling products.

Avoiding the trappings of unnecessary ingredients and proprietary blends, N.O. Limits™ is comprised of four primary ingredients with attached ethyl esters to enhance effectiveness, plus antioxidants to enhance safety and long term efficacy. Additionally, while the pump alone may be impressive enough for some, N.O. Limits™ combines Arginine Ethyl Ester with Lysine Ethyl Ester for the first time ever in an NO product to maximize natural growth hormone (GH) secretion.

Now, before we explain exactly why increased blood flow, increased nutrient uptake, long-lasting pumps, and maximized GH secretion can make an athlete feel as though there are N.O. Limits™ to what he or she can do, it is first our duty to explain how.

N.O. Limits™, N.O. Nonsense

Traditional NO-boosting products use the NO precursor L-Arginine or a varied structure of this amino acid in order to provide substrate for NO conversion1. N.O. Limits™ not only provides the substrate using the new ethyl ester technology, it also utilizes compounds that control Nitric Oxide production while also providing anti-oxidants to control free radical release that Nitric Oxide and physical exercise can cause. By paying close attention to these details, N.O. Limits™ aims to not only prolong the efficacy of nitric oxide in users, but also potentially correct the fact that NO-boosters do not work in all users.

What is Nitric Oxide?

Nitric Oxide (NO) is a highly important signalling molecule in the body. Interestingly, it is a gas, and even more interesting is that it is also a free radical. While major research has recently indicated that NO is intimately related to brain, stomach, kidney, liver and lung function, the major interest bodybuilders and athletes have in NO is that it regulates blood flow and can influence nutrient uptake.  Initially referred to as the Endothelium-Derived Relaxing Factor (EDRF), NO achieves its most tangible effect by causing the outer wall (the smooth muscle) of the blood vessel to relax and dilate. More specifically, NO binds to an enzyme known as guanylyl cyclase which catalyzes the conversion of Guanosine Triphosphate (GTP) to 3’,5’-cyclic Guanosine Monophosphate (cGMP). It is the cGMP that signals the smooth muscle to relax2.  The net result of this reaction allows more nutrient-rich blood to travel through the artery thereby causing the effect commonly known as the “pump”. Not only is the pump mentally motivating, but there is also speculation that it may promote
increased protein synthesis in the stressed muscle3, and may increase creatine synthesis4.

In summary, N.O. Limits™ is the best choice of NO-promotion available today, and is excellent for:

  •  Promoting workout “pumps”
  •  Improving blood flow
  • Increasing nutrient uptake • Maximizing hGH release
  • Positive Mental motivation

N.O. Limits™ can be stacked with XCEED™ to form the perfect pre-workout cocktail that will maximize your performance as you train, and promote your recovery as you rest. The addition of Replenish™ post workout along with Glucophase XR™ confers added benefit in terms of nutrient partitioning, active recovery, and maximal cellular signalling to ensure the best results of each and every workout. Going to the gym should be about maximum results for your effort and it is for this reason that you should set N.O. Limits™ to your expectations.

For best results, take one serving of N.O. Limits™ 30 minutes prior to workout. Use N.O. Limits™ for no longer than eight weeks at a time before cycling off for six to eight weeks.

 



References
1. Schmidt HH, Walter U. NO at work. Cell. 1994 Sep 23;78(6):919-25.
2. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med. 1993 Dec 30;329(27):2002-12.
3. Paddon-Jones D, Borsheim E, Wolfe RR. Potential ergogenic effects of arginine and creatine supplementation. J Nutr. 2004 Oct;134(10 Suppl):2888S-2894S; discussion
2895S.
4. Barbul A. Arginine: biochemistry, physiology, and therapeutic implications. JPEN J Parenter Enteral Nutr. 1986 Mar-Apr;10(2):227-38.
5. Foster G. L, Schoenheimer R, Rittenberg D. Studies in protein metabolism V. The utilization of ammonia for amino acid and creatine formation in animals. J. Biol. Chem. 1939
127: 319-327.
6. Tatsumi R, Hattori A, Ikeuchi Y, Anderson JE, Allen RE. Release of hepatocyte growth factor from mechanically stretched skeletal muscle satellite cells and role of pH and nitric
oxide. Mol Biol Cell. 2002 Aug;13(8):2909-18.
7. Tatsumi R, Liu X, Pulido A, Morales M, Sakata T, Dial S, Hattori A, Ikeuchi Y, Allen RE. Satellite cell activation in stretched skeletal muscle and the role of nitric oxide and hepatocyte
growth factor. Am J Physiol Cell Physiol. 2006 Jun;290(6):C1487-94.
8. Balon TW, Nadler JL. Evidence that nitric oxide increases glucose transport in skeletal muscle. J Appl Physiol. 1997 Jan;82(1):359-63.
9. Higaki Y, Hirshman MF, Fujii N, Goodyear LJ. Nitric oxide increases glucose uptake through a mechanism that is distinct from the insulin and contraction pathways in rat skeletal
muscle. Diabetes. 2001 Feb;50(2):241-7.
10. Yearick ES, Nadeau RG. Serum amino acid response to isocaloric test meals. Am J Clin Nutr. 1967 Apr;20(4):338-44.
11. Dhanakoti SN, Brosnan JT, Herzberg GR, Brosnan ME. Renal arginine synthesis: studies in vitro and in vivo. Am J Physiol. 1990 Sep;259(3 Pt 1):E437-42.
12. Castillo L, Chapman TE, Yu YM, Ajami A, Burke JF, Young VR. Dietary arginine uptake by the splanchnic region in adult humans. Am J Physiol. 1993 Oct;265(4 Pt 1):E532-9.
13. Wilkerson JE, Batterton DL, Horvath SM. Exercise-induced changes in blood ammonia levels in humans. Eur J Appl Physiol Occup Physiol. 1977 Dec 22;37(4):255-63.
14. Callis A, Magnan de Bornier B, Serrano JJ, Bellet H, Saumade R. Activity of citrulline malate on acid-base balance and blood ammonia and amino acid levels. Study in the
animal and in man. Arzneimittelforschung. 1991 Jun;41(6):660-3.
15. Suminski RR, Robertson RJ, Goss FL, Arslanian S, Kang J, DaSilva S, Utter AC, Metz KF. Acute effect of amino acid ingestion and resistance exercise on plasma growth
hormone concentration in young men. Int J Sport Nutr. 1997 Mar;7(1):48-60.
16. Isidori A, Lo Monaco A, Cappa M. A study of growth hormone release in man after oral administration of amino acids. Curr Med Res Opin. 1981;7(7):475-81.
17. Gianotti L, Maccario M, Lanfranco F, Ramunni J, Di Vito L, Grottoli S, Muller EE, Ghigo E, Arvat E. Arginine counteracts the inhibitory effect of recombinant human insulin-like
growth factor I on the somatotroph responsiveness to growth hormone-releasing hormone in humans. J Clin Endocrinol Metab. 2000 Oct;85(10):3604-8.
18. Schwemmer M, Bassenge E. New approaches to overcome tolerance to nitrates. Cardiovasc Drugs Ther. 2003 Mar;17(2):159-73.
19. Berges A, Van Nassauw L, Bosmans J, Timmermans JP, Vrints C. Role of nitric oxide and oxidative stress in ischaemic myocardial injury and preconditioning. Acta Cardiol.
2003 Apr;58(2):119-32.
20. Das UN. Folic acid says NO to vascular diseases. Nutrition. 2003 Jul-Aug;19(7-8):686-92.
21. Mayer B, Hemmens B. Biosynthesis and action of nitric oxide in mammalian cells. Trends Biochem Sci. 1997 Dec;22(12):477-81.
22. Bassenge E, Fink B. Tolerance to nitrates and simultaneous upregulation of platelet activity prevented by enhancing antioxidant state. Naunyn Schmiedebergs Arch Pharmacol.
1996 Feb;353(3):363-7.
23. Smith AR, Hagen TM. Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alphalipoic
acid. Biochem Soc Trans. 2003 Dec;31(Pt 6):1447-9.
24. Bridgeman MM, Marsden M, MacNee W, Flenley DC, Ryle AP. Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with Nacetylcysteine.
Thorax. 1991 Jan;46(1):39-42.
25. Stroes ES, van Faassen EE, Yo M, Martasek P, Boer P, Govers R, Rabelink TJ. Folic acid reverts dysfunction of endothelial nitric oxide synthase. Circ Res. 2000 Jun
9;86(11):1129-34.
26. Wilmink HW, Stroes ES, Erkelens WD, Gerritsen WB, Wever R, Banga JD, Rabelink TJ. Influence of folic acid on postprandial endothelial dysfunction. Arterioscler Thromb Vasc
Biol. 2000 Jan;20(1):185-8.Click here to read Links
27. Das UN. Folic acid says NO to vascular diseases. Nutrition. 2003 Jul-Aug;19(7-8):686-92.Click here to read Links
28. Verhaar MC, Wever RM, Kastelein JJ, van Dam T, Koomans HA, Rabelink TJ. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial
hypercholesterolemia. Circulation. 1998 Jan 27;97(3):237-41.
29. Symons JD, Rutledge JC, Simonsen U, Pattathu RA. Vascular dysfunction produced by hyperhomocysteinemia is more severe in the presence of low folate. Am J Physiol
Heart Circ Physiol. 2006 Jan;290(1):H181-91


Current Reviews: 2

This product was added to our catalog on Monday 02 April, 2007.

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No claims found on this web page or in print have been evaluated by the Food and Drug Administration. No descriptions listed on this web page are intended to diagnose, treat, cure, or prevent any disease. No claim or opinion about weight loss, bodybuilding or general health on this web page is intended to be, nor should be construed to be, medical advice. Please consult with a healthcare professional before starting any weight loss diet or exercise program. Descriptions and images are the property of the respective product manufacturers. Actual product may differ from image posted. This site is best viewed in 1024x768. Please contact us about any concerns about our nutritional supplements.


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N.O. Limits
Awsome product better than NO2 and NITRIX. Get it it!!! ..

5 of 5 Stars!

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