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"Not Your Daddy’s Stim-Stack—AMP
and H.E.A.T."
by Loki
And why we Think Rather Highly of Getting Down on this Stuff
Author’s note: this article will be somewhat of a departure from normal
M&M protocol in that much of what will be presented and discussed below
is based strictly on conjecture, and reflects at best only a very limited understanding
of the full pharmacological effects of Ergopharm’s AMP. However, we at
M&M feel that the subjective experiences and feedback from numerous stackers,
our detailed knowledge of H.E.A.T.’s workings, a small amount of disclosure
surrounding ‘geranamine’, and our familiarity with other stimulants
which have been researched extensively by the scientific community, gives us
just enough to comfortably go out on a limb with this one. Consider yourself
warned.
Like most, I’m a big fan of positive synergy. Getting more bang for your
perennial buck, the biggest return on your investment, reaping the genuinely
memorable yields—there’s just so much to love about a singular ‘sum
of parts’ that leaves the most lasting of impressions when you’re
fortunate enough to experience its magnificence under those ‘just-right’
conditions.
For us fitness enthusiasts, more often than not, it’s the workout that
defines our days and offers us that portal which enables us to temporarily transcend
the mundane and just feel free, complete, and altogether comfortable with ourselves
and our state of being. Chances are—if you’re anything like me—you
can recollect your past “perfect workouts” better than you keep
track of your friend’s birthdays. And so what if you only vaguely recall
your first kiss but can wax Joycean in the locker-room for hours about the time
you front-squatted ‘til you puked? You know full well you tied the knot
with gym-going well before you ever even considered settling down with your
‘other better half.’
And that’s what this article is all about—our desire to share with
you the miracle pairing that may very well fan the flame between you and the
iron to an all new level: the ErgoLean AMP™-Avant Labs H.E.A.T. ™-stack.
A taste of stimulant synergy that not only rocks the socks off ephedrine and
caffeine, delivers indomitable workout performances with the consistency of
tax day, and assaults appetite with a “one shot, one kill” mentality,
but heck, even has Par Deus back exercising again.
The Recipe and the Theory
Geranamine™, the corner-stone active in AMP, is a naturally occurring
adrenaline-like stimulant that makes one fast forget about ephedrine when combined
with a catecholamine-potentiating substance like caffeine. Yeah, it’s
that good. According to Patrick Arnold, the researcher who discovered ‘geranamine’,
there is as-of-yet undisclosed research that suggests the compound is a potent
inhibitor of norepinephrine (NE) uptake centrally in the brain, which would
deprive the brain of its basic negative-feedback mechanism for regulating/curtailing
NE release.
And while I can’t cite (much less see) this data, believe you me when
I say I buy it wholly and completely. In fact, based on my own personal experiences
with stimulants, amphetamines, and psychotropics, I’m willing to speculate
that the energized ‘AMP-euphoria’ that so many users have reported
represents a cocktail of heightened NE release and uptake inhibition, coupled
with increases—and possibly additional uptake inhibition—of serotonin
(5-HT) and dopamine (DA). Or rather, just consider the fact that an elevated
cortisol/stress (re: exercise & NE) response in conjunction with elevated
5-HT signaling in the amygdala is highly associated with dominant, energized,
and hypervigilant states in adult humans (1,2,3,4). Sounds a little like AMP,
now doesn’t it?
Others with a great deal of knowledge and familiarity with psychotropics have
also ventured similar speculation. So while the exact details of AMP’s
pharmacology remain unclear, we can venture with a great deal of certainty that
AMP acts on stress and pleasure neurotransmitters in a manner similar to ephedrine
and caffeine, but with greater serotonigenic/dopaminergic and noradrenergic-uptake-blocking
components.
So where does our own H.E.A.T. stack™ factor into this equation? Simple:
we include it to provide a one-two synergy punch that not only heightens the
neurotransmitter effects-profile of AMP, but also stimulates additional mood
and repartitioning pathways, both centrally and peripherally. Ultimately, it
ends up looking a little like this:
Hordenine: inhibitor of NE uptake, just like geranamine (and tyramine as well),
allowing for further maintenance of exercise-level neurotransmitter activity.
Hordenine is also a selective MAO-B inhibitor, rendering it capable of so it
will preferentially increase dopamine through this pathway (5,6). Not only that,
hordenine-inhibition of MAO-B also renders a much greater portion of the phenylethylamine
(PEA) content in AMP’s chocamine orally bioavailable. PEA, a naturally
occurring neuro-stimulant similar in many ways to amphetamine, is normally rapidly
metabolized by MAO-B, and rendered null as a stimulant. With the HEAT/AMP stack,
we bypass this bioavailability issue, and enable a much greater yield of active,
stimulatory PEA (7).
Eviodamine: enhances the thermogenic/lipolytic effect of AMP (8), and is also
a vasodialator, which will help to counteract some of the AMP-induced vasoconstriction
and lower blood pressure (8,9). Thirdly, since eviodamine has been shown to
inhibit gastric emptying and increase plasma CCK, it’s hardly a stretch
to mention this as just one more dynamic that enables the AMP/HEAT stack to
show all the pretenders out there the true meaning of ‘appetite-suppression’
(10).
Alpha-Y™: an alpha-2c adrenoreceptor antagonist (11), Alpha-Y™
will inhibit DA negative feedback and increase central dopaminergic tone—which
is already going to be elevated from the caffeine/chocamine, tyramine, MAO-B
inhibition of hordenine, and potentially geranamine™ as well (12,13).
The result is a significant shift in the mood-inducing neurotransmitter effects
of the stack to favor energy and euphoria, rather than stress and ‘tweak.’
Moreover, modest disclosure from Ergopharm has made it known that geranamine
acts in an adrenal stimulant fashion, and, unlike other yohimbine analogues,
Alpha- Y™ is a negative feedback-blocker of norepinephrine’s big-time
catecholamine cousin epinephrine (adrenaline) (14), thereby making the AMP/HEAT
stack a true surge of NE, adrenaline, & DA, which some possible other neurotransmitter
‘goodies’ to boot.
Tyramine: stimulates NE release (15) and, perhaps even better when we consider
the NE uptake-inhibiting properties of geranamine, prevents it from being metabolized
by inhibiting MAO-A (16). Also preferentially increases DA via three mechanisms:
1. direct conversion by the enzyme CYP-2D6, 2. a decrease in DA metabolism as
a result of its MAO-inhibiting effects, and 3. it’s ability to strongly
inhibit DA uptake—IC50 in the nanomolar range (16,17)
The result is an inferno tag-team guaranteed to spark cognition into the stratosphere
and ignite motivation to white-hot levels. The fact that the AMP/H.E.A.T. stack
will also act synergistically to improve mood, potently bury appetite, and strongly
stimulate lipolysis ‘taint terribly shabby either, while we’re on
the subject.
Now We’re Cookin’ with Catecholamines
I must say, I truly do pity the scant few AMP-nonresponders out there, because
this stack puts an ‘S’ on my chest in the gym, workout after workout,
without fail. Think I’m hyping you? Then listen to some assorted feedback
from others who’ve dabbled in this Molitov cocktail of a stimulant stack.
When asked to evaluate AMP/H.E.A.T. at different doses, one tester reported
that three H.E.A.T. and two AMP produced mood-enhancing effects "much more
pronounced than AMP [or H.E.A.T.] alone"). When he bumped the dosage up
to six capsules of H.E.A.T. and four capsules of AMP, he responded enthusiastically
that he blew through a double full-body depletion workout in a single session
with “so much energy… the whole workout flew by. I actually enjoyed
it.” People—that just doesn’t happen. Anyone who’s ever
immersed themselves in the draconian squalor of high-rep, lactic-acid-threshold
depletion strength-training knows that ‘flew by’ and ‘enjoyment’
are about as appropriate for characterizing those sorts of grueling workouts
as ‘rather mild’ would be for describing this year’s hurricane
season.
On neither side of that analogy is there a pun.
Another user—an individual not much for waxing poetic during his supplement
reviews—broke it down and got right to the point (after taking 3 capsules
of H.E.A.T. and 4 capsules of AMP) by saying: “holy sh*t it was awesome…
the energy was amazing—a beautiful synergy between AMP and HEAT for sure.”
Needless to say, the AMP/H.E.A.T. stack has definitely been christening a few
believers of late. “Oh my holy God, the [central nervous system] stimulation
is f’n unreal,” reports a third tester; “methinks this is
definitely far superior [to] ephedrine/caffeine.” Only ‘definitely
superior’ to that stimulatory slouch ephedrine and caffeine; hmm *pun
alert*, perchance we should go back to the drawing board…
No, the bottom line is the H.E.A.T./AMP stack has redefined stimulant synergy,
and ushered in a new era in pre-workout energizers. It is a combination that
has made us see the value in sometimes setting aside competing business interests
when a certain fit enables two separate companies’ products to unite in
the name of owning some imitators.
As always, leading the way in performance-enhancement innovation stand Avant
Labs, Ergopharm, and the AMP/H.E.A.T. Stack, the new-jack stim-stack that will
have you seeing fireworks well beyond the Fourth of July. Remember to always
assess your tolerance to each supplement separately, and to combine both with
caution and care. Cheers all, and ‘happy blast-off’.
ErgoLean AMP™ and geranamine™ are both trademarks of Ergopharm/Proviant
Tech., all rights reserved. "
Taken from current issue of Mind and Muscle Magazine on www.avantlabs.com
