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It is important to note that although the evidence for the claims made for MSM is still weak, it is an extremely safe supplement. A toxicological study in rats found no adverse effects from 2 g/kg acutely or 1.5 g/kg for 90 days; this is about the equivalent of six times the maximum recommended human dose [3]. Toxicity has not been reported in animal studies, adverse effects have not been noted in human studies, and long-term users of 2 g or more daily have reported no ill effects [2]. However, there is one concern. MSM has been detected in the brains of humans taking MSM supplements, where it is not normally detectable [3]. This was not associated with changes in the concentrations of important cerebral metabolites, and this combined with the animal data would indicate that it is unlikely that MSM has any important effect on the brain [4].
The recommended dosage for MSM is in the range of 1-6 grams daily, although some physicians have recommended up to 20 grams daily [3]. A study in 1975 indicated that MSM recovery after oral administration was only 3%, suggesting utilization or modification in the gut or liver [3]. This may be why a high dose is needed, but it is also noteworthy that the presence of detectable MSM in the brain after supplementation would indicate that a supplement is enough to significantly increase plasma levels of the compound. Given the present information, it can be concluded that MSM is a safe supplement that may be effective for a variety of purposes, primarily for joint support, but further studies are needed to prove efficacy.
If you have any questions or comments regarding this article, please email dvdtlsn@bulknutrition.com.
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