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Medium Chain Triglycerides
By David Tolson

1. What are medium chain triglycerides (MCTs)?

Medium chain triglycerides are fats that contain 6-12 carbon fatty acids (as opposed to long chain triglycerides, those generally found in the diet, which contain more than 12 carbons per fatty acid). Medium chain triglycerides contain less calories per gram than other fats, and when consumed are processed differently in the body. They are commonly used in hospitals as a calorie source for patients who are having trouble digesting food, but also have application as a weight loss aid and rapid source of energy. They have the additional benefit of protecting the liver and gut from various toxins (one of them being alcohol) (1).

2. What benefits do MCTs have?

Multiple human and animal studies indicate that supplementation with medium chain triglycerides during calorie restriction has the ability to increase energy expenditure, reduce fat mass, improve nitrogen retention, preserve lean mass, and reduce appetite in the short term, but these effects have not been demonstrated in the long term (2, 3), and there is some indication that metabolic adaptation prevents long-term efficacy (2). For this reason, they are most beneficial when cycled and used for 1-2 week periods along with caloric restriction. From the available data, it is estimated that the use of MCTs for a two week period will reduce fat mass by up to 1.5 pounds (3), but this is assuming that all long-chain triglycerides are replaced with MCTs. More realistically, supplementation with a smaller amounts will have a modest effect on fat mass while aiding in muscle sparing and suppressing the appetite.

MCTs may also be useful as a pre-exercise energy source, primarily on a low-carbohydrate diet, but the data are contradictory, with some studies on exercise performance showing a benefit and some being equivocal (4, 5). The studies that show a benefit from MCTs tend to be when MCT was used as a stand-alone, indicating that they are an effective fuel source for exercise when carbohydrates are absent, but they probably do not improve performance to a significant degree when carbohydrates are ingested.

Finally, MCTs can be used as a healthy source of calories and dietary fat, even (and perhaps especially) while bulking. MCTs have a very good safety profile, and have been used in many trials at up to 1 g/kg with no ill effects (7).

3. What are some of the best supplements with MCTs?

If you have any questions or comments regarding this article, please email dvdtlsn@bulknutrition.com.


No part of this article may be reproduced in any form without the permission of David Tolson or Mike McCandless.


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References
1. Kono H, Fujii H, Asakawa M, Yamamoto M, Matsuda M, Maki A, Matsumoto Y. Protective effects of medium-chain triglycerides on the liver and gut in rats administered endotoxin. Ann Surg. 2003 Feb;237(2):246-55 [abstract]

2. Krotkiewski M. Value of VLCD supplementation with medium chain triglycerides. Int J Obes Relat Metab Disord. 2001 Sep;25(9):1393-400 [abstract]

3. St-Onge MP, Jones PJ. Physiological effects of medium-chain triglycerides: potential agents in the prevention of obesity. J Nutr. 2002 Mar;132(3):329-32 [abstract]

4. Van Zyl CG, Lambert EV, Hawley JA, Noakes TD, Dennis SC. Effects of medium-chain triglyceride ingestion on fuel metabolism and cycling performance. J Appl Physiol. 1996 Jun;80(6):2217-25 [abstract]

5. Angus DJ, Hargreaves M, Dancey J, Febbraio MA. Effect of carbohydrate or carbohydrate plus medium-chain triglyceride ingestion on cycling time trial performance. J Appl Physiol. 2000 Jan;88(1):113-9 [abstract]

6. St-Onge MP, Lamarche B, Mauger JF, Jones PJ. Consumption of a functional oil rich in phytosterols and medium-chain triglyceride oil improves plasma lipid profiles in men. J Nutr. 2003 Jun;133(6):1815-20 [abstract]

7. Traul KA, Driedger A, Ingle DL, Nakhasi D. Review of the toxicologic properties of medium-chain triglycerides. Food Chem Toxicol. 2000 Jan;38(1):79-98 [abstract]






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