Your Final Pre-Workout Solution
Scivation has already made Workout Nutrition a household phrase. In fact,
many people wouldn’t even think of training without their Xtend and Substance
WPI keeping them anabolic and anticatabolic during a grueling training session.
What more could you ask for? Well, Scivation has made pre-workout supplementation
a thoughtless endeavor as well. Imagine if you could take the scientifically-proven,
synergistic ingredients to guarantee you have all bases covered and to assure
that you get the skin-bursting pumps, mind-blowing energy and unbelievable
endurance to help you attack the weights like a beast. If you’re like anyone
here at Team Scivation, this is a dream come true. Time to stop dreaming.
Read on and find out what this dream supplement is and why it is such a huge
breakthrough…
vasoXplode—Pre-workout Performance, Nitric Oxide, and Energy Booster
We have formulated vasoXplode around ingredients that are scientifically
proven to increase performance and muscle growth. vasoXplode contains synergistic
ingredients that work together to take the results you will see to the next
level and beyond.
1. Creatine + Citrulline Malate
• Synergistically increases performance
2. Creatine + Beta-Alanine
• Synergistically increases performance
and lean mass gains
3. Citrulline Malate + Arginine
• Increases blood flow and amino
acid deliver to skeletal muscle, leading to increased protein synthesis (muscle
growth)
4. Tyrosine + ALCAR + Caffeine
• Increases energy and mental
focus while delaying fatigue, allowing you to workout harder and longer.
Let’s take a more indepth look at VasoXplode’s ingredients.
CreaSci Blend
(Creatine Monohydrate, Di Creatine Malate)
Creatine is used in the high-energy phosphate or ATP-PCr system to regenerate
ATP. ATP, the body's main source of energy, is a molecule of adenosine (adenine
+ the sugar ribose) linked to three phosphate molecules by high-energy bonds.
Breaking of the two outer bonds results in the release of energy.
When the most outer bond is broken, the energy is released and ADP and Pi
are left behind. Creatine, which is bonded to a phosphate ion, transfers
energy to the ADP and Pi molecule by breaking its own bond. This regenerates
the ATP molecule, which means one now has more energy to use. Skeletal muscle
has a limited storage of creatine. Therefore supplementing with creatine
increases your ability to form ATP and therefore increases the available
energy for exercise (Casey et al. 1996 & 2000). Creatine has been shown
to:
• Increase muscle size and strength (Willoughby, 2001)
• Increase power output (Becque, 2000)
• Increase high-intensity exercise performance (Tarnopolsky,
2000)
• Increase work capacity (Rico-Sanz, 2000)
Creatine is one of the most scientifically proven-effective supplements on
the market, with creatine monohydrate being the form used in most studies.
VasoRush™ Blend
Citrulline Malate, L-Arginine Alpha KetoGlutarate 2:1, (Di-L-Arginine)-L-Malate,
Citric Acid, (Di-L-Arginine) Orotate
The rate-limiting step of amino acid uptake into skeletal
muscle is the transportation of the amino acids through the blood to the
skeletal muscle, which is governed by blood flow (Wolfe, 2004). NO vasodilates
blood vessels, thereby increasing blood flow. This increase when combined
with exercises means greater blood flow and greater amino acid deliver and
uptake in the working skeletal muscle. Exercise itself results in an increase
in NO production, and the increased blood flow created by exercise is believed
to be linked to the increase in protein synthesis post workout (Douglas et
al., 2004). Di-Arginine Orotate, AAKG, Di-Arginine Malate, and Citrulline
Malate all increase NO production and blood flow to skeletal muscle.
Citrulline-Malate has been shown to increase the rate
of oxidative ATP production during exercise and the rate of phosphocreatine
replenishment post exercise (Bendahan, 2002). Increasing the rate of ATP
production during exercise would increase performance and energy.
Citrulline-Malate also has anti-fatigue properties due
to its ability to decrease ammonia levels and prevent against metabolic acidosis
(Callis, 1991). Decreasing the sensation of fatigue would allow one to workout
harder and longer, and thereby burn more calories and lose more fat.
Both Citric Acid and Malic Acid (Malate) are intermediates
in the Kreb’s cycle, which produces ATP. Adding citric acid and malic acid
to VasoXplode aids in ATP production.
H-Primer Blend
(Beta-Alanine, NAC)
Beta-Alanine
It has been shown that skeletal muscle carnosine levels
are correlated with performance during high-intensity exercise (Suzuki, 2002).
Carnosine is an important metabolic buffer in skeletal muscle (Suzuki, 2002),
which means it helps maintain the acid-base balance in the presence of high
H+ concentrations. High levels of H+ during exercise cause fatigue and decrease
performance.
Beta-alanine is one of the two amino acids (histidine
being the other) that makes up the dipeptide carnosine (L-beta-alanyl-L-histidine).
Growing research shows Beta-alanine to be a very effective performance enhancers
and lean mass building supplement. Research shows:
• Beta-Alanine availability is the limiting factor in
muscle carnosine synthesis (Hill, 2007).
• Muscle carnosine levels were higher after 10 weeks of
beta-alanine supplementation than after 4 weeks, showing that beta-alanine’s
effects are best experienced over long term supplementation (Hill, 2007).
• Beta-alanine supplementation increases total work done
during aerobic exercise (Hill, 2007).
• Beta-alanine enhances endurance performance (Zoeller,
2006)
• Beta-Alanine delays the onset of neuromuscular fatigue
(Stout, 2006)
• Adding beta-alanine to creatine supplementation leads
to greater increases in lean mass than creatine alone (Hoffman, 2006).
It is clear that current research shows Beta-Alanine to be an effective performance
enhancer and enhances lean mass gains when combined with creatine.
NAC
N-acetyl-cysteine (NAC) is derived from the non-essential
amino acid cysteine. Because cysteine is very unstable, supplementing with
NAC allows one to get the benefits of cysteine. NAC is an antioxidant itself
(Aruoma, 1989) and is also used to synthesize the antioxidant glutathoine.
Glutathione is a powerful antioxidant and also regenerates vitamin C and
E (Bounous, 1999)
Since intense exercise depletes glutathione (Sen, 1999),
supplementation of NAC can is beneficial to increase glutathione levels.
Oxidative stress caused by free radicals (H+), causes fatigue and muscular
soreness. Supplementing with NAC will enhance athletic performance by scavenging
these free radicals (Lands, 1999).
BrainDrive Blend
(N-Acetyl Tyrosine, ALCAR, Caffeine)
N-Acetyl-L-Tyrosine
Tyrosine is a nonessential amino acids used to make the
catecholamine neurotransmitters dopamine, norepinephrine, and epinephrine,
thyroid hormones, and the skin pigment melanin. Stress, such as exercise,
depletes the amount of dopamine and norepinephrine in the brain. Tyrosine
supplementation has been shown
• Decrease the negative effects of stress (Banderet, 1989)
• Decrease fatigue and increase cognitive performance
(Neri, 1995)
• Decrease cardiovascular stress and enhance cognitive
activity (Dollins, 1995)
ALCAR
The amino acid L-Carnitine plays a vital role in energy
metabolism, specifically the transport of fatty acids into mitochondria where
they can be oxidized. ALCAR is the acetylated form of carnitine and is the
most popular form of supplemental carnitine. ALCAR is a potent antioxidant
shown to have anti-aging, cardio-protective, cognitive enhancing, and adaptogen
properties. ALCAR increases exercise performance by
• Increasing fat oxidation (Hongu, 2003)
• Decreasing muscle soreness (Giamberardino, 1996)
• Decreasing lactic acid accumulation (Siliprandi, 1990).
Caffeine
Caffeine, a plant alkaloid belonging to the drug class
methylxanthines and is found in natural sources such as coffee beans, tea
leaves, cocoa beans, and other plants, is the world’s most widely used stimulant.
Caffeine is a Central Nervous System (CNS) stimulant shown to delay fatigue
and improve cognitive performance.
Caffeine acts as an adenosine receptor antagonist. Adenosine
decreases the release of stimulatory/excitatory neurotransmitters (i.e. norepinephrine
[NE]). Therefore, blocking the adenosine receptor allows a greater excitation
to occur by increasing NE’s ability to activate the adrenergic receptors.
Caffeine inhibits phosphodiesterase (PDE), causing a build-up
of cAMP levels and greater effect of NE on fatty acid lipolysis. PDE blunts
lipolysis; therefore inhibiting PDE allows lipolysis to proceed at an accelerated
rate. The end result is there are more fatty acids available for oxidation
after consumption of caffeine, which is one of the ways caffeine is believes
to increase performance.
D,L-Phenylalanine
D,L-Phenylalanine is a 50/50 mix of D-Phenylalanine and L-Phenylalanine.
L-Phenylalanine is an essential amino acid while D-Phenylalanine is a non-protein
amino acid that is not used in protein synthesis. Phenylalanine can be metabolized
to PEA and is also a precursor for norepinephrine and dopamine.
B-Vitamins
(50mg B6, 50mg B5, 100 mcg B12, 75mg Niacin)
The B vitamins are essential to whole body energy metabolism,
We included the B vitamins in VasoXplode to ensure your body has what it
needs to perform at its full potential.
Wrap-Up
VasoXplode is formulated to allow you to increase the
intensity of your workouts while delaying fatigue, which results in greater
progress being made. VasoXplode increases energy production and power output,
decreases H+ accumulation and fatigue, and increases blood flow and the deliver
of amino acids to skeletal muscle, making it an all-in-one pre-workout powerhouse.
We highly recommend combining 1 serving of VasoXplode with 1 serving of Primal
EAA 15-20 minutes pre-workout to give your body EVERYTHING it needs to perform
and progress like never before.
References:
CreaSci Blend
Becque MD. Lochmann JD. Melrose DR. Effects of oral creatine supplementation
on muscular strength and body composition. Medicine & Science in Sports
& Exercise. 32(3):654-8, 2000 Mar.
Casey, A, Constantin-Teodosiu D, Howell S, Hultman E, Greenhaff PL. (1996)
Creatine ingestion favorably affects performance and muscle metabolism during
maximal exercise in humans. Am J Physiol. Jul;271:E31-7.
Casey A, Greenhaff PL. (2000).Does dietary creatine supplementation play
a role in skeletal muscle metabolism and performance?Am J Clin Nutr. Aug;72(2
Suppl):607S-17S. Review.
Rico-Sanz J. Mendez Marco MT. Creatine enhances oxygen uptake and performance
during alternating intensity exercise. Medicine & Science in Sports &
Exercise. 32(2):379-85, 2000 Feb.
Tarnopolsky MA, MacLennan DP. Creatine monohydrate supplmentation enhances
high-intensity exercise performance in males and females. Int J Sport Nutr
Exerc Metab. 2000 Dec ;10(4) :452-63.
Willoughby DS. Rosene J. Effects of oral creatine and resistance training
on myosin heavy chain expression. Medicine & Science in Sports &
Exercise. 33(10):1674-81, 2001 Oct.
VasoRush Blend
Bendahan D, Mattei JP, Ghattas B, Confort-Gouny S, Le Guern ME, Cozzone PJ.
Citrulline/malate promotes aerobic energy production in human exercising
muscle.
Br J Sports Med. 2002 Aug;36(4):282-9.
Callis A, Magnan de Bornier B, Serrano JJ, Bellet H, Saumade R. Activity
of citrulline malate on acid-base balance and blood ammonia and amino acid
levels. Study in the animal and in man. Arzneimittelforschung. 1991 Jun;41(6):660-3.
Douglas, Borsheim, and Wolfe. "Potential Ergogenic Effects of Arginine and
Creatine Supplementation" J Nutr. 2004 Oct;134(10 Suppl):2888S-2894S.
Wolfe, et. al., In vivo muscle amino acid transport involves two distinct
processes. Am J Physiol Endocrinol Metab. 2004 Jul;287(1):E136-41.
Tyrosine
Banderet, LE, and Lieberman HR. Treatment with tyrosine, a neurotransmitter
precursor, reduces environmental stress in humans. Brain Res Bull 22: 759-762,
1989..
Dollins AB, Krock LP, Storm WF, Wurtman RJ, Lieberman HR. L-tyrosine ameliorates
some effects of lower body negative pressure stress. Physiol Behav. 1995
Feb;57(2):223-30.
Neri DF, Wiegmann D, Stanny RR, Shappell SA, McCardie A, McKay DL. The effects
of tyrosine on cognitive performance during extended wakefulness. Aviat Space
Environ Med. 1995 Apr;66(4):313-9.
ALCAR
Giamberardino MA, Dragani L, Valente R, Di Lisa F, Saggini R, Vecchiet L.
Effects of prolonged L-carnitine administration on delayed muscle pain and
CK release after eccentric effort. Int J Sports Med 1996 Jul;17(5):320-4
Hongu N, Sachan DS. Carnitine and choline supplementation with exercise alter
carnitine profiles, biochemical markers of fat metabolism and serum leptin
concentration in healthy women. J Nutr 2003 Jan;133(1):84-9
Siliprandi N, Di Lisa F, Pieralisi G, Ripari P, Maccari F, Menabo R, Giamberardino
MA, Vecchiet L. Metabolic changes induced by maximal exercise in human subjects
following L-carnitine administration. Biochim Biophys Acta 1990 Apr 23;1034(1):17-21
Beta-Alanine
Hill CA, Harris RC, Kim HJ, Harris BD, Sale C, Boobis LH, Kim CK, Wise JA.
Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations
and high intensity cycling capacity. Amino Acids. 2007 Feb;32(2):225-33.
Hoffman J, Ratamess N, Kang J, Mangine G, Faigenbaum A, Stout J.
Effect of creatine and beta-alanine supplementation on performance and endocrine
responses in strength/power athletes. Int J Sport Nutr Exerc Metab. 2006
Aug;16(4):430-46.
Stout JR, Cramer JT, Mielke M, O'Kroy J, Torok DJ, Zoeller RF. Effects of
twenty-eight days of beta-alanine and creatine monohydrate supplementation
on the physical working capacity at neuromuscular fatigue threshold. J Strength
Cond Res. 2006 Nov;20(4):928-31.
Suzuki Y, Ito O, Mukai N, Takahashi H, Takamatsu K. High level of skeletal
muscle carnosine contributes to the latter half of exercise performance during
30-s maximal cycle ergometer sprinting. Jpn J Physiol. 2002 Apr;52(2):199-205.
Zoeller RF, Stout JR, O'kroy JA, Torok DJ, Mielke M. Effects of 28 days of
beta-alanine and creatine monohydrate supplementation on aerobic power, ventilatory
and lactate thresholds, and time to exhaustion. Amino Acids. 2006 Sep 5
NAC
Aruoma O,et al. (1989) The antioxidant action of N-acetylcysteine: its reaction
with hydrogen peroxide, hydroxyl radical, superoxide and hypochlorous acid.
Free Radical Biol.Med.6:593-597.
Bounous G, Molson J. (1999) Competition for glutathione precursors between
the immune system and the skeletal muscle: pathogenesis of chronic fatuge
syndrome. Med Hypothesis 53;(4): 347-349.
Lands LC, Grey VL and Smountas AA. (1999) Effect of a cysteine donor on muscular
performance.J Appl Physiol. 87 (4):1381-1385.
Sen CK. (1999) Glutathione homeostasis in response to exercise training and
nutritional supplements. Molecular & Cellular Biochemistry. 196:31-42.
Label Information
Supplement Facts
Serving Size: 2 Scoops
Servings per Container: 20
Amount Per Serving
Vitamin B3 (Niacinimide)
75mg 375%
Vitamin B5 (pantothenic acid) 50mg 500%
Vitamin B6 (Pyridoxine HCL) 50mg 2,500%
Vitamin B12 100mcg 1,667%
VasoXplode Propietary Blend: 16,200mg
VasoRuch Blend:
(citrulline malate, L-Arginine Alpha Ketoglutarate 2:1, (Di-Arginine)-L-Malate,
Citric Acid, (Di-L-Arginine) Orotate
8,250mg
CreaSci Blend:
(Creatine Monohydrate, Dicreatine Malate) 2,500mg
H-Primer Blend:
Beta-Alanine, N-Acetyl-Cysteine 2,500mg
BrainDrive Blend:
(Acetyl-L-Carnitine, N-Acetyl-Tyrosine, Caffeine (USP) DL-Phenylalanine) 2,450mg
INGREDIENTS: Natural and Artificial Flavors, Acesulfame Potassium, Sucralose,
Yellow #5.
Directions:
We recommend taking vasoXplode 30-45 minutes pre-training. For optimal results,
consume Scivation Xtend™ during training.
WARNING:
Keep out of the reach of children. Always consult a physician prior to using
any dietary supplement.
